10 May, 2016
This webinar on “Synthesis and integration of real-world evidence in network meta-analyses and outcome prediction” gives the participants an understanding of important methodological key deliverables achieved by the IMI GetReal team. Part of the IMI GetReal project has been devoted to establishing a coherent framework for assessing and bridging the efficacy-effectiveness gap between treatment outcomes in clinical trial and real-world populations.
The focus of this webinar is on the use of network meta-analysis for evidence synthesis and on the extension of its conclusions in real-world settings, using predictive modelling. A set of recommendations are provided on how to simultaneously incorporate different sources of evidence into the analysis, i.e. randomized controlled trial and registry data on aggregated (summary) and individual participant basis. It is shown how to extrapolate insights and findings when the studied interventions are adopted in a realistic setting. The proposed strategies are substantiated by selected case studies.