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Launch PragMagic - an innovative tool to assist pragmatic trial design

8 June, 2017 



Rick Grobbee
Professor of Clinical
University Medical Center
Iris Goetz
Research Advisor 
Epidemiology, Global Health Outcomes, Eli Lilly         
Evert Hoogendoorn 
Strategist and Gamedesigner, IJsfontein   
Mira Zuidgeest 
Assistant Professor,
University Medical Center Utrecht


This webinar was the launch of ‘PragMagic’ (, the web-based tool that is a key output of GetReal.

A pragmatic trial aims to capture the true effect of a treatment strategy in the real world. As generalisability of trial results to routine clinical practice is considered the key aspect of a pragmatic trial, generalisability plays a central role in this tool.

PragMagic is a decision support tool and educational tool for pragmatic trial design and protocol evaluation, developed in collaboration with serious gaming company IJsfontein. In a user-friendly (and dare we say fun) way, PragMagic gives insight into the possible consequences of more pragmatic trial design choices and operational challenges on generalisability, risk of bias, precision, stakeholder & ethical acceptability, cost and duration.

The PragMagic Tool aims to increase the value and feasibility of pragmatic trials by informing stakeholders when designing and assessing pragmatic clinical trials.

In this webinar, we briefly introduced how pragmatic trials can address the need for real world evidence; discussed the operational challenges and the forces at work that we captured in the tool, showed how gaming principles were used to get the information across in a user-friendly manner, and concluded with a live demo of the tool.

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This webinar is part of a series of outputs on IMI GetReal foreseen throughout 2016 and 2017: